Efficient production of solid dispersions by spray drying solutions of high solid content using a 3-fluid nozzle

PREPARATION AND EVALUATION OF TERNARY MIXING ITRACONAZOLE SOLID DISPERSIONS BY SPRAY DRYING METHOD S.Rajarajan,

The present study aims to experiment the solid dispersion of poorly water soluble drug itraconazole as model drug by spray drying method with the use of PEG/HPMC polymer blends, the influence of polymer compatibility on the degree of molecular dispersion of itraconazole solid dispersions are prepared by ternary mixing and polymer blends are also evaluated for DSC, XRD and in vitro dissolution t...

preparation and evaluation of naproxen solid dispersions using spray drying method

Improving Dissolution of Meloxicam Using Solid Dispersions

Meloxicam is a poorly water soluble non steroidal anti-inflammatory drug and antipyretic agent. The aim of the present work was to investigate the effect of different types of carriers on in vitro dissolution of meloxicam. Meloxicam solid dispersions were prepared by physical mixing, co-grinding and solvent evaporation methods with polyethylene glycol (PEG) 6000. The effect of solubilization by...

Improving Dissolution of Meloxicam Using Solid Dispersions

Meloxicam is a poorly water soluble non steroidal anti-inflammatory drug and antipyretic agent. The aim of the present work was to investigate the effect of different types of carriers on in vitro dissolution of meloxicam. Meloxicam solid dispersions were prepared by physical mixing, co-grinding and solvent evaporation methods with polyethylene glycol (PEG) 6000. The effect of solubilization by...

Characterization of Olanzapine – Solid dispersions.

Aim: To enhance the aqueous solubility of olanzapine by using the Solid dispersion technique. Solid dispersions of Olanzapine were prepared by the dispersion method using using PGS and SSG as carriers. Drug:carrier ratios such as 1:1, 1:2, 1:4, 1:6, 1:8 and 1:10 were tried for optimization. Characterization was done by phase solubility, in vitro release, saturation solubility, permeation, wetta...